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Mechanistic studies further propose that increased intestinal permeability (leaky gut) may allow bacterial metabolites and endotoxinssuch as lipopolysaccharideto enter the circulation and activate systemic and neuroinflammatory pathways ( In a Chd8 deficient mouse model, excessive epithelial proliferation and microvillus abnormalities were linked to BBB dysfunction and microglial activation

Singh AK, Kumar A, Karmakar D, Jha RK