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Ligands (e.g., antibodies, peptides or small molecules) may be conjugated with the nanoparticles and these ligands are known to selectively bind to receptors that are over expressed in tumour cells, thus, delivering the antioxidant directly at the tumour site [299, 300]

Determination of NADP + /NADPH ratio In order to determine the effect of the Polydatin inhibitor targeting the activity of glutathione in the antioxidant mechanism on the NADPH and NADP + levels in HCT-116 colorectal cancer cells, the NADP + /NADPH ratio was determined

Furthermore, CB-839 increased the radiosensitivity of head and neck squamous carcinoma (HNSCC) and NSCLC cells both in vitro and in a xenograft mouse model by abolishing GSH synthesis 47,48 , making it useful for concurrent chemotherapy and radiotherapy in a clinical setting

This product contains beta-alanine which may cause a flushing or itching sensation that should resolve on its own