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Besides its role in cancer, amino acid metabolism has been reported as an important participant in the development of metabolic diseases such as diabetes and obesity, as well as cardiovascular diseases, autoimmune diseases and neurological diseases

Acknowledgments The authors acknowledge kind sponsorship by Ferring Pharmaceuticals to support in vitro experimental work to determine the role of GH in carbohydrate and lipid metabolism in granulosa cell lines performed in the laboratory of KK and JY

The mice in the control (ND group, n = 10, 0.86% Met) and model (D + ND group, n = 10, 0.86% Met) groups were fed a normal diet, whereas the mice in the intervention group (D + MS group, n = 10, 1.72% Met) were fed a Met-supplemented diet

Metformin attenuates ROS via FOXO3 activation in immune cells