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Moreover, 75% of the participants reported that the composition moisturized the skin at a very high level, and all the participants reported that it did not irritate or dry out the skin

While this might seem counterintuitive, studies in mice suggest that hypoxia could potentially be used as a therapy for mitochondrial dysfunction, with the researchers proposing that hypoxia could be beneficial owing to two different mechanisms: the first involving a reduction in O 2 tension, resulting in a decrease of reactive oxygen species (ROS), while the second involving activation of HIFs (Hypoxia-Inducible Factors), resulting in decreased production of ATP by OXPHOS and a shift to glycolysis (Jain et al., 2016, 2019

Curiously, vascular smooth muscle cells that typically express eNOS also express low nNOS levels, which can partially regulate vasodilation in the absence of eNOS [37]