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In fact, GSH metabolism impairment has been associated with several diseases such as cancer, kwashiorkor, seizure, Alzheimers and Parkinsons disease, liver disease, cystic fibrosis, sickle cell anaemia, acquired immunodeficiency disease syndrome (AIDS), heart attack, stroke, diabetes [8,14,15], several mitochondrial disorders [16], Niemann Pick type C disease [17] and progressive multiple sclerosis [18,19]

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Dimerization, disulphide bond formation and metal ion acquisition are the canonical SOD1 PTM steps en route to forming a stable and active enzyme 5,6,7