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6.2 Hypoxia In the normal adult intervertebral disc (IVD), oxygen partial pressure gradually decreases from about 10% in the outer annulus fibrosus to less than 1% in the central region, placing the entire disc in a state of continuous hypoxia, which may further decrease during degeneration (Urban, 2002)

91 Furthermore, growth factor signaling, which helps regulate colonic epithelial cell injury and repair, also regulates the expression of TJ protein expression in intestinal epithelial cells

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