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SKU: 17511675651
Price: 22.01 USD
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S.UddinM

In contrast, under oxidative stress conditions, Cys273 and Cys288 cysteines on Keap1 protein are rapidly oxidized, leading to the loss of Keap1 protein-mediated ubiquitination modifications and the translocation of Nrf2 to the nucleus, where it binds to multiple AREs on DNA and initiates the transcriptional expression of multiple antioxidant proteins [131]