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Strikingly, we found that TDP-43 SUMOylation was selectively modified by SUMO2 and SUMO3, but not SUMO1, specifically under stressed conditions

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they create what researchers refer to as a massive immunological "energy sink." Because the immune cells (particularly T-cells and memory lymphocytes) are trapped in a state of severe oxidative stress, they are forced to consume excessive amounts of the host's energy just to survive the ongoing cellular damage and attempt repairs

Recent studies suggest that the tumor microenvironment plays a significant role in determining the type of fuel that tumors use to grow