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Dosage adjustments or closer monitoring may be necessary to ensure safe and effective use of the medication in this population

The high expression of TXN and TXNRD1, as well as the low expression of TXNIP group exhibited lower levels of tumor immune infiltration

For drugs that are highly extracted by the liver, bypassing hepatic sites of elimination (eg, in hepatic cirrhosis with portosystemic shunting) will result in substantial increases in drug availability, whereas for drugs that are poorly extracted by the liver (for which the difference between entering and exiting drug concentration is small), shunting of blood past the liver will cause little change in availability

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