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It is usually used when symptoms of parkinsonism cause a certain degree of disability and, usually, its use is avoided at the beginning of the disease, since it usually causes dyskinesia and worsen other symptoms such as postural hypotension and psychiatric symptoms

The Cu2+ ion is coordinated by the histidine imidazole nitrogen and the N-terminal amino group of glycine, forming a specific metal-peptide complex

In this sense, while high doses of NR did not lead to improvements in insulin sensitivity in pre-diabetic patients [16,54], low doses of NMN improved insulin sensitivity in pre-diabetic women [99]