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Other alkaloids, such as nuciferine (from lotus, Nelumbo nucifera ), likewise inhibit inflammatory signaling and oxidative stress in vascular cells, contributing to anti-atherosclerotic effects (Xiao et al., 2023)

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In hepatocytes and adipocytes it reduces the activity of key lipogenic enzymes: Acetyl-CoA carboxylase (ACC) , a key step in fatty acid synthesis Fatty acid synthase (FAS) , the enzyme creating long chains of fatty acids Lipoprotein lipase (LPL) in adipocytes, reduces uptake of circulating triglycerides into fat cells Imagine it as turning valves in a pipeline, you close the inflow (lipogenesis), open the outflow (lipolysis)

doi:10.1002/cmdc.202100395