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Importantly, IL-6 elevation occurred without corresponding CRP increases, and IL-6 correlated with IL-8, suggesting persistent immune activation rather than nonspecific inflammation

The inhibition of the AKT signalling pathway, a pathway frequently overactivated in tumours and associated with resistance to therapies, including radiation, is one of the key mechanisms underlying this radiosensitising effect (Faiz et al

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Solubility is intrinsically a mesoscale phenomenon, making full first-principles simulation too costly to contemplate for routine usage, and depends on phenomena like crystal polymorphism and ionization state in complex and nonlinear ways, complicating attempts to build simple multilinear models