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Description

Heme Triggers TLR4 Signaling Leading to Endothelial Cell Activation and Vaso-Occlusion in Murine Sickle Cell Disease

At elevated extracellular iron levels, soluble A binds to Fe 3+ and promotes its reduction to Fe 2+ , which is difficult to dissociate, and additional senile plaques are created as a result of the rapidly precipitation of A caused by the ROS produced in this phase (Ha et al