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It is difficult for any drug to inhibit K-Ras by outcompeting GTP/GDP for the binding site ( Figure 9 ) ( Figure 8 Figure 9 New technology is enabling the development of more targeted and adjuvant therapies that reduce toxicity to normal cells and decrease the likelihood of cancer cell resistance

Similarly, chlorinated hydrocarbons like perchloroethylene (PCE) and trichloroethylene (TCE), commonly used in dry cleaning and industrial cleaning, are linked to a higher incidence of bladder cancer with long-term exposure (Wynder and Goldsmith, 1977