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GPR146 in adipose tissue drives adipose-liver crosstalk and promotes hepatic steatosis in mice

1 Introduction Cells sense and adapt to hypoxia through the activity of hypoxia inducible factors (HIFs) and their regulatory hydroxylases, three HIF prolyl hydroxylase domain enzymes (PHD1-3) and an asparaginyl hydroxylase (factor-inhibiting HIF, or FIH)