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10.1016/j.biomaterials.2019.119467 87 Latunde-DadaG

Hyperalgesia and Allodynia: Cases of hyperalgesia and allodynia have been reported with opioid therapy of any duration (see WARNINGS)

Additionally, findings from a recent study indicate that high doses of PPR may lead to cardiac adverse effects in rat (unpublished data), further complicating its safety profile

However, while alcohol may provide temporary relief, it often results in a vicious cycle where increased consumption leads to heightened depressive symptoms