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Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice

The electron transport chain (ETC) establishes an imbalance of protons across the inner mitochondrial membrane (IMM) and generates mitochondrial membrane potential, which leads to complex V (also known as ATP synthase) producing ATP (100)

These findings uncovered an underrecognized source of HBsAg, leading to changes in the trial design and expectations for the end point of new treatments for chronic HBV