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Caspase-3 is a key enzyme in the apoptosis pathway

JW: Investigation, Writing review & editing

(PubMed) Hagen TM, Vinarsky V, Wehr CM, Ames BN

86 It has been observed in animal models that sustained glucocorticoid stimulation can increase the excitability of glutamatergic neurons and simultaneously decrease the number and plasticity of astrocytes, in addition to decreasing neuronal dendrite connectivity in the hippocampus and frontal cortex, leading to depression