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Conclusion: We identify novel genetic risk variants and complex genetic architecture of cirrhosis and HCC in which metabolic dysfunction is both an independent risk factor and a multiplicative accelerator of disease risk when combined with a high genetic burden or other causes of liver disease

GlyNAC (glycine and N-acetylcysteine) supplementation improves impaired mitochondrial fuel oxidation and lowers insulin resistance in patients with type 2 diabetes: results of a pilot study