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The features of the cell lines are described in detail in the site and the references from 71, 76105, and reviewed in ref

Although neutralizing antibody titers are indeed associated with protection against infection (primarily because they opsonize pathogens, making it easier for macrophages to recognize them), excessive antibody production can have untoward effects such as vaccine-associated enhanced disease (VAED), potentially mediated by the phenomenon of antibody-dependent enhancement or pathogenic priming

In this article, we will explore some of the various theories that are currently in circulation, which outline the cause as: Excessive production of porphyrin by skin bacteria stimulated by B12 A cobalt allergy Relative deficiency of vitamin B12 cofactors A detoxification reaction Vitamin B12 Acne The Work of Skin Bacteria

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