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24 The incidence of Grade 3 or higher liver injury during ICI therapy was significantly higher in patients with viral hepatitis compared to those without (28% vs

Its optimized 3PO derivative, PFK158, showed enhanced tolerability and reduced glycolytic flux in preclinical studies, was selected as the first-in-human, first-in-class PFKFB3 inhibitor, and has entered phase I clinical trials for advanced solid malignancies [256]

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However, its efficacy remains unclear as no differences in proinflammatory cytokines and leukocytes or clinical outcome parameters could be observed, probably due to rapid saturation of the filter with donor leukocytes as examined in porcine lung EVMP ( ex vivo perfusion systems operate as closed systems, ports at various locations are incorporated for additive supply and perfusate replacement or sample collection