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While these model systems provide valuable insights into liver function and drug metabolism, they fail to mimic the intricate three-dimensional (3D) architecture, cellular heterogeneity, and zonation observed in the native liver

Typical signs associated with an unhealthy oral microbiome may include biofilm formation on the teeth

Among these, gutka, naswar, paan, khaini, and zarda were locally prepared and available in loose packaging, while paan masala was tested using the most common commercial brand (Rajni Brand)