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VPS35 deficiency is also shown to impair Trem2 trafficking back to the trans-golgi network, leading to increased Trem2 accumulation in the lysosome [175], but overexpression of Trem2 mitigates the proinflammatory phenotype in VPS35 KO microglia [175]

Hospitals are sorted into quintiles based on the proportion of dual-eligible stays among Medicare fee-for-service (FFS) and managed care stays between July 1, 2018, and June 30, 2021 (that is, the FY 2023 Hospital Readmissions Reduction Program's applicable period)

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