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The Terry Beirn Community Programs for Clinical Research on AIDS

PMID: 19159286

For instance, it has been shown that after an experimental psychologic stress, the evoked cortisol response in fatigued breast cancer survivors is much smaller than that in nonfatigued ones, pointing to the involvement of the HPA axis in cancer-related fatigue (286)

The body is locked in a state of high oxidative stress and low energy production, unable to break the cycle without targeted nutritional intervention to restart the methylation gears