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Other gene mutations include those in the: HJV gene (hemojuvelin ) HAMP gene (hepcidin) TFR2 gene (transferrin receptor-2) SLC40A1 gene (ferroportin disease) FTH1 gene (mutation in the iron responsive element of H-ferritin ( FTH1 ) mRNA) Transfusional iron overload: Transfusional iron overload typically affects patients with hematologic disorders who require chronic red blood cell (RBC) transfusions, such as: Transfusion-dependent thalassemia Sickle cell disease Myelodysplastic syndrome (MDS) Ineffective erythropoiesis: Expanded erythroid marrow of patients with ineffective erythropoiesis results in erythroblast-mediated release of which inhibits the synthesis of hepcidin in the liver, resulting in increased iron absorption in the gut

10.1016/b978-0-12-405933-7.00004-4 23 DalalP

While CMS has previously treated section 1886(d)(8)(E) reclassifications as one among many reclassifications provided for under section 1886(d) and so limited its scope in several ways, we now read it to provide that a 412.103 reclassification functions the same as if the reclassifying hospital had physically relocated into a geographically rural area