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In the cytosol and nucleus, several enzymes create localized ROS microdomains: xanthine oxidoreductase (interconverting XDH and XO) at cytosolic and endothelial surfaces, monoamine oxidases on the outer mitochondrial membrane facing the cytosol, dihydrolipoamide dehydrogenase within the PDH/OGDH complexes and NOX isoforms positioned at the nuclear envelope (Moloney et al

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Research suggests that supplementing with glutathione may effectively increase blood plasma levels

These medications can be used alone or in combination with levodopa to extend effectiveness