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doi: 10.1016/j.stem.2017.06.004

Biliverdin is converted to bilirubin, a potent antioxidant, while carbon monoxide modulates vasodilation and anti-inflammatory processes ( HMOX1 as a crucial ferroptosis-related differentially expressed gene, suggesting that alterations in its expression levels may impact cell survival ( in vitro studies on macrophage-derived foam cells, has confirmed that HO-1 plays a dual role in ferroptosis: low expression enhances cell viability and reduces lipid peroxidation, whereas high expression can induce ferroptosis in macrophage-derived foam cells ( As research progresses, more transcription factors have been identified as regulators of HO-1 expression, with increasing potential for clinical applications

FDA, through its Modernization Act 2.0 and 3.0, promotes the use of advanced non-animal models (221)

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