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High-throughput screening identified clofazimine as a broad-spectrum synergist with fluconazole, caspofungin, and AmB, and others, enhancing activity against Candida albicans , Cryptococcus neoformans , and additional fungal pathogens (Robbins et al., 2015)

This critical step was modulated by the interaction between monocytes and the surface molecules of endothelial cells 52,53

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There is also recent data which suggest that genetic alterations of the receptor by which B12 is transported into nerve tissue and the brain, may lead to a lower B12 uptake