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SKU: 18223539457
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Muscle function, tone, and endurance are iron dependent

Nrf1 knockout mice die in utero but fetal hepatocytes and embryonal fibroblasts from these animals have lower GSH levels and are more susceptible to oxidative stress (Kwong et al., 1999

We employed diamide, an established thiol-oxidizing agent that oxidizes GSH to GS-SG [22], to induce GSR-mediated NADPH consumption during reduction of GS-SG back to GSH (Fig 1A)