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[DOI] [PubMed] [Google Scholar] 15.Costello M.J., Brennan L.A., Basu S., Chauss D., Mohamed A., Gilliland K.O., Johnsen S., Menko S., Kantorow M

Persistent welts, severe itching, and worsening reactions indicate mast cell activation requiring further medical intervention

Moreover, most clinical trials continue to rely on liver enzymes and imaging endpoints without stratifying patients according to inflammatory phenotype or cytokine signatures