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POI protein of interest the invention includes embodiments of methods of purifying a protein of interest (POI) comprising contacting a first fusion protein comprising the POI fused to the C-terminus of an intein C-fragment with a second fusion protein comprising an intein N-fragment and a purification tag to form a complex between the first fusion protein and the second fusion protein, wherein the purification tag is located at an intein split junction, which is at the C-terminus of the intein N-fragment

525 Similarly, dual inhibitors 3b and 3 f, which target ATX and LPAR1, effectively eliminate paclitaxel-resistant breast cancer stem cells and reduce melanoma metastasis

H.PatelS

Studies have confirmed that the combination of glycolysis inhibitors and classical immunomodulators exhibits a significant synergistic effect