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FFAs also activate inflammatory pathways, including NF-B and JNK, and further activate protein kinase c beta II (PKC-II) and protein kinase c delta (PKC-) in human muscle, which disrupts insulin signaling by impairing IRS function, further propagating hyperglycemia and metabolic dysfunction ( de novo lipogenesis ( de novo lipogenesis through sterol regulatory element-binding protein 1c (SREBP-1c) activation, increasing the synthesis of triglycerides and very-low-density lipoproteins (VLDL), contributing to MASLD and systemic dyslipidemia Figure 4 ( Figure 4 CRHM Syndrome-associated dyslipidemia is marked by elevated triglycerides, reduced high-density lipoprotein (HDL), and increased small-dense low-density lipoprotein (LDL), compounding cardiovascular risk

Not all roots of infected plants show the same phenotypic changes

(Discrepancy is within the known variability in this data system, and statistical moving averages, smoothers, etc

(6) Christensen, K