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A recent study also showed that ISL alleviated doxorubicin-induced hepatocyte toxicity by exciting the Nrf2/antioxidants axis and following inhibition of NF-B, mainly by upregulating SIRT1 (Al-Qahtani et al., 2022)

pranlukast, 10 M

FBUT, fluorescein breakup time

125 Despite this, the atheroprotective functions of 12/15-LOX-derived metabolites remain controversial, as 12/15-LOX-ApoE-double-deficient mice were found to be less prone to atherogenesis than ApoE / littermates with fully functional 12/15-LOX enzymes