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Description

Baicalin alleviates ulcerative colitis (UC) through dual-targeting JAK2/STAT3 phosphorylation during Th17 differentiation and IL-17 production, while suppressing IL-17RA expression in macrophages to inhibit NF-B activation and M1 polarization, thereby disrupting IL-17-mediated inflammatory crosstalk between the Th17/M1 macrophage immune pathways [63]