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however, for toxicity prediction, cumulative drug exposure, particularly cumulative AUC over the treatment course, appears more informative than isolated peak or trough measurements ( Bayesian forecasting represents a further refinement, combining population pharmacokinetic models with individual patient covariates and measured drug concentrations to generate patient-specific pharmacokinetic parameter estimates and optimize dosing

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2019 Aug 3 [cited 2024 Nov 24];35(8):7816

C., Bu G., Liu C