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Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats

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Two subjects in the fasting group withdrew from the trial at the end of the first cycle during the washout period and the fourth cycle, one subject experienced an adverse event (AE) on the second day of dosing in the second cycle, and the investigator judged that withdrawal from the study would be in the best interest of the subject to withdraw from the trial

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