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Description

Consistent with this protective role, we found that mice lacking Fth in cardiomyocytes develop ferroptosis-induced cardiomyopathy

N.GellettW.AyersK

Elkattawy S, Dhanoa P, Kotys J, Fichadiya H, Eckman A

Cytosolic and mitochondrial pools of malate and OAA are connected by two transporters the malate-2OG transporter (Slc25a11) and the glutamate-aspartate transporter (Slc1a3) and by the interconversion of aspartate and glutamate into OAA and 2OG by the cytosolic and mitochondrial isoforms of the glutamate-oxaloacetate transaminase, Got1 and Got2, respectively