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46 When extended-release naltrexone versus buprenorphine in combination with naloxone was studied for relapse prevention in OUD, 47 treatment with the buprenorphine naloxone or long-acting injectable antagonist naltrexone (XR-NTX) produced a similar decreased risk of relapse in those with an OUD who inject opioids

It is not obvious that the methionine cycle would need to be supported by a biochemical like glutathione, whose formation is considered to be dependent on the function of the methionine cycle