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Hence, from a clinical standpoint, surgery for HT is not a first-line option and is typically reserved for patients with compressive symptoms, cytological suspicion of malignancy, or coexisting nodular disease (51)

Acta Histochem 123(4):151712 Khosravi A, Hasani A, Rahimi K, Aliaghaei A, Pirani M, Azad N et al (2020) Ameliorating effects of curcumin-loaded superparamagnetic iron oxide nanoparticles (SPIONs) on the mouse testis exposed to the transient hyperthermia: a molecular and stereological study

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Studies have shown that oxidative phosphorylation of glucose, along with electron transfer chain reactions used to generate energy, also produces substantial free radicals, which are further elevated in the aging brain (Gemma et al., 2007