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[8] [11] [12] [13] [14] [15] [16] [17] A 1961 report by Paul OHollaren, MD, of Shadel Hospital in Seattle, Washington, led to a study that led to the widespread use of IV infusions of NAD+ for the treatment of addiction

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This indicates that as the retina matures or degenerates photo-oxidation becomes a main contributor to the generation and accumulation of ROS