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Carbon monoxide-releasing molecule-3 can inhibit the inositol-requiring enzyme 1 pathway and decrease the expression of NLRP1, NLRP3, cleaved-caspase-1, cleaved-caspase-11, GSDMD, IL-1, and IL-18 by increasing the concentration of carbon monoxide in the spinal cord to promote the recovery of motor function in SCI rat models (Zheng et al., 2019)

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Sepsis leads to a reduction in the rates of mitochondrial state 3 respiration

Nature 443 , 226229 (2006)