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There is large individual variation in the intensity of pain experienced by patients during fixed appliance therapy

1 Introduction Systemic Lupus Erythematosus (SLE) is a chronic autoimmune inflammatory disease featuring complex pathogenesis that affects various organ systems, leading to significant mortality and morbidity ( Among the many factors influencing immunosuppressant-related serious adverse effects, genetic variabilityparticularly in the form of single nucleotide polymorphisms (SNPs)has gained considerable attention

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