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Many health organizations agree that removing combustion reduces exposure to harmful byproducts, though they also stress that vaping is not harmless and long-term data is still developing

Nicotine dependence is a chronic and relapsing condition, and many people who smoke tobacco are dependent on nicotine (USHHS, 2020)

The association between those components in metabolism of estrogen-regulated pathways has been explored [18, 40, 41]