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Conversely, CO-GHD patients tend to be less insulin-resistant than AO-GHD patients (84), and their IGF-I levels are generally lower than their AO-GHD counterparts due to relatively lower intra-portal insulin levels

Further evaluations, such as fasting glucose and insulin levels, lipid profile, and oral glucose tolerance testing, may be indicated, especially in individuals who are overweight or obese, to screen for associated metabolic abnormalities ( 5 Integrative potential of natural bioactives in complementary therapeutics Conventional medical treatments for PCOS primarily aim at symptom management rather than targeting the underlying pathophysiology of the disorder

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