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Also, some studies have remarked on the relevance of quercetin as a non-toxic and safe bioactive compound with a marked antiviral activity, being suggested as a potential tool against viral-associated IBD [124]

Its hepatoprotective effects are attributed to multiple mechanisms, including the modulation of lipid metabolism, antioxidant activity, anti-inflammatory properties, enhancement of insulin sensitivity, and alterations in gut microbiota composition

Indeed, in experimental models, butyrate treatment has been shown to induce autophagy and improve clearance of misfolded proteins, as well as improve synaptic and cognitive function in mice with neurodegenerative pathology [56]

52,53 Enzymes such as protein kinase C (PKC), MAPK, and protein kinase A (PKA) modulate NOX activation, whereas the tumor suppressor p53 regulates both antioxidant and prooxidant responses, promoting ROS production and apoptosis in cancer cells