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However, variability among iPSC lines limits consistency in 3D AD models, while in vivo models, though informative, tend to focus on specific phenotypes and fail to capture the full disease spectrum [46]

In the effort to characterize the binding site of G in GIRK channels, cross-linking experiments revealed the binding of four G subunits per tetramer, with each G binding to one channel subunit (Sadja et al., 2002)

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