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We can hypothesize that apoC1 may have different functions according to its distribution between lipoproteins (with a pro-atherogenic effect when associated with VLDL and an anti-atherogenic effect when associated with HDL) and that qualitative changes of apoC1 occurring in clinical situations as diabetes and atherosclerosis may also modify its properties and expression pattern

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doi: 10.1002/hep.20274

In the United States alone, APAP misuse accounts for approximately 500 deaths annually, in addition to nearly 100,000 poisoning-related emergency calls, 50,000 emergency department visits, and 10,000 hospitalizations (67)