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This neurodegenerative disease is characterized by the progressive loss of upper motor neurons in the cerebral cortex and lower motor neurons in the brain stem and spinal cord, leading to muscle weakness, and progressing into muscle atrophy and paralysis, which culminates in respiratory failure and death [1, 2]

Curr Cancer Drug Targets 8:187198 Wu J, Su H-k, Yu Z-h, Xi S-y, Guo C-c, Hu Z-y, Qu Y, Cai H-p, Zhao Y-y, Zhao H-f (2020) Skp2 modulates proliferation, senescence and tumorigenesis of glioma

Thus, SOD is an important antioxidant defense in nearly all living cells exposed to oxygen

C11-BODIPY(581/591), an oxidation-sensitive fluorescent lipid peroxidation probe: (micro)spectroscopic characterization and validation of methodology