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(4) and the study assesses the incidence of chemotherapy-induced overall chronic peripheral neurotoxicity (referred to as overall neurotoxicity below) or the incidence of chemotherapy-induced severe chronic peripheral neurotoxicity (referred to as severe neurotoxicity below) as endpoints

It is mediated by the RIPK1/RIPK3/MLKL signaling axis, ultimately leading to plasma membrane rupture, release of cellular contents, and inflammatory responses

doi: 10.1021/acsnano.4c08508 14 KuipersMEvan Doorn-WinkKCJHiemstraPSSlatsAM

doi: 10.1039/9781849737876-00037 Dutertre, Sebastien, Undheim, Eivind, Pineda, Sandy S., Jin, Ai-Hua (Jean), Lavergne, Vincent, Fry, Bryan G., Lewis, Richard J., Alewood, Paul F