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TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons

NAC significantly prolonged the latencies to jerks and clonic generalized seizures during the 30-minute analysis, with this effect not being dose-dependent

The down-regulation of the p53 gene protects hair cells from Bcl2 family translocation, cytochrome c translocation, caspase3 activation, and ultimately cell death, as it operates upstream of the mitochondrial apoptotic pathway